Compatibilidade entre medicamentos injetáveis e nutrição parenteral: evidências e implicações para a segurança do paciente

Compatibilidade entre medicamentos injetáveis e nutrição parenteral

Abstract

Parenteral nutrition is an essential therapy for patients who cannot ingest or absorb nutrients through conventional routes, and is administered directly into the bloodstream. Simultaneous administration of medications with parenteral nutrition requires rigorous care, since incompatibility between the components can compromise the efficacy of the treatment and patient safety. This study aimed to identify, in the scientific literature, evidence on the compatibility between injectable medications and parenteral nutrition, in addition to listing the main risks associated with this practice. For this purpose, an integrative review was carried out in the MEDLINE, SciELO and Google Scholar databases. The selection of articles considered studies published in the last 10 years that addressed the interaction between medications and parenteral nutrition. Six articles were selected, highlighting that medications such as ampicillin, fosphenytoin and furosemide demonstrated incompatibility with parenteral nutrition, while others, such as dopamine and morphine, showed compatibility. The analysis revealed that physical and chemical interactions can affect the stability of the solutions, with risks of precipitation or degradation. It is concluded that the simultaneous administration of drugs with PN must be carefully monitored, based on scientific evidence and clinical guidelines, to ensure the safety and efficacy of the treatment.